Pharmacokinetic And Pharmacodynamic Drug Interactions Ppt To Pdf

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In particular, poly-therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 , and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.

For example, a drug that causes chronic nausea or mouth pain may result in poor intake and weight loss.

Drug Drug Interaction phenomena that occurs when the effects pharmacodynamics or pharmacokinetics of a drug are altered by prior administration or coadministration of a second drug Hartshorn, EA, Tatro, DS: Drug Interactions, , Facts and Comparisons, St. Louis, MO. Most drugs must be lipid soluble to cross cell membranes and reach their site of action The net effect of drug metabolism is to increase water solubility and facilitate renal excretion Phase I metabolism primarily involves oxidative metabolism via the Cytochrome P CYP family of enzymes Phase II metabolism conjugates the previously oxidized molecule with a water soluble weak acid glucouronic acid, tauric acid, etc enhancing overall water solubility. Cytochrome P Nomenclature, e. Johns Wort.

Drug interaction

If your institution subscribes to this resource, and you don't have a MyAccess Profile, please contact your library's reference desk for information on how to gain access to this resource from off-campus. Please consult the latest official manual style if you have any questions regarding the format accuracy. Drug interactions occur when one drug modifies the actions of another drug in the body. Drug interactions can result from pharmacokinetic alterations, pharmacodynamic changes, or a combination of both. Interactions between drugs in vitro eg, precipitation when mixed in solutions for intravenous administration are usually classified as drug incompatibilities, not drug interactions. Although hundreds of drug interactions have been documented, relatively few are of enough clinical significance to constitute a contraindication to simultaneous use or to require a change in dosage.

Drug interactions can have desired, reduced or unwanted effects. The probability of interactions increases with the number of drugs taken. The high rate of prescribed drugs in elderly patients year-old patients take an average of 5 drugs increases the likelihood of drug interactions and thus the risk that drugs themselves can be the cause of hospitalization. Drug interactions occur on pharmacodynamic and pharmacokinetic levels. Examples of pharmacodynamic interactions are simultaneous administration of a NSAID and phenprocoumon additive interaction , or of aspirin and ibuprofen antagonistic interaction. Pharmacokinetic interactions occur at the levels of absorption e.

A drug interaction is a change in the action or side effects of a drug caused by concomitant administration with a food, beverage, supplement, or another drug. A cause of a drug interaction involves one drug which alters the pharmacokinetics of another medical drug. Alternatively, drug interactions result from competition for a single receptor or signaling pathway. Both synergy and antagonism occur during different phases of the interaction between a drug, and an organism. For example, when synergy occurs at a cellular receptor level this is termed agonism , and the substances involved are termed agonists. On the other hand, in the case of antagonism, the substances involved are known as inverse agonists.

food-drug interactions 1.ppt

Copy embed code:. Automatically changes to Flash or non-Flash embed. WordPress Embed Customize Embed. URL: Copy. Presentation Description Pharmacokinetic drug interactions are dealt in this presentatio in a way to understand easily.. Naina Mohamed Pharmacologist Drug Interactions: Drug Interactions Definition A drug interaction occurs when a drug interferes in a negative or positive way with another drug. It Can increase or lower the drug levels or their efficacy or increase their toxicity.

Drug-drug interactions DDIs constitute an important problem in postmarketing pharmacovigilance and in the development of new drugs. The effectiveness or toxicity of a medication could be affected by the co-administration of other drugs that share pharmacokinetic or pharmacodynamic pathways. For this reason, a great effort is being made to develop new methodologies to detect and assess DDIs. In this article, we present a novel method based on drug interaction profile fingerprints IPFs with successful application to DDI detection. IPFs were generated based on the DrugBank database, which provided 9, well-established DDIs as a primary source of interaction data. The model uses IPFs to measure the similarity of pairs of drugs and generates new putative DDIs from the non-intersecting interactions of a pair.

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Drug Interactions—Principles, Examples and Clinical Consequences

Drug Drug Interaction phenomena that occurs when the effects pharmacodynamics or pharmacokinetics of a drug are altered by prior administration or coadministration of a second drug Hartshorn, EA, Tatro, DS: Drug Interactions, , Facts and Comparisons, St. Louis, MO. Most drugs must be lipid soluble to cross cell membranes and reach their site of action The net effect of drug metabolism is to increase water solubility and facilitate renal excretion Phase I metabolism primarily involves oxidative metabolism via the Cytochrome P CYP family of enzymes Phase II metabolism conjugates the previously oxidized molecule with a water soluble weak acid glucouronic acid, tauric acid, etc enhancing overall water solubility. Cytochrome P Nomenclature, e. Johns Wort.

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