Radiotherapy In Head And Neck Cancer Pdf

File Name: radiotherapy in head and neck cancer .zip
Size: 2639Kb
Published: 19.01.2021

Head and Neck Cancer pp Cite as.

Concomitant radiochemotherapy vs radiotherapy alone in patients with head and neck cancer

The primary objective of the present randomized phase III trial was to compare the 3-yr survival rate of patients treated with standard fractionated radiotherapy RT alone or with the same RT concomitantly with cisplatin DDP or carboplatin Cb. There were no significant differences in complete response rates between patients treated with RT alone or combined chemoradiotherapy. However, median time to progression TTP and overall survival OS were significantly longer in patients treated with concomitant chemoradiotherapy.

Thus, median TTP was 6. Similarly, median OS was At 3 yr follow-up, Patients treated with concomitant chemoradiotherapy experienced more frequently severe hematological toxicity. The present study clearly demonstrated that concomitant chemoradiotherapy with platinum analogs significantly prolongs 3-yr survival and median OS in patients with locally advanced HNC compared to conventional RT alone. This is a preview of subscription content, access via your institution.

Rent this article via DeepDyve. An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts.

Cancer ; 40 — Tannock IF, Browman G. Lack of evidence for a role of chemotherapy in the routine management of locally advanced head and neck cancer. J Clin Oncol ; 4 — Al-Sarraf M, et al. Concurrent radiotherapy and chemotherapy with cisplatin in inoperable squamous cell carcinoma of the head and neck: an RTOG study. Cancer ; 59 — Br J Radiol ; 64 — Carboplatin as a potentiator of radiation therapy. Cancer Treat Rev ; 12 Suppl A — Enhancement of radiation-induced cell kill by platinum complexes carboplatin and iproplatin in V79 cells.

Douple EB. Keynote address: Platinum-Radiation interactions. NCI Monogr ; 6 — Biologic and clinical developments of cisplatin combined with radiation: concepts, utility, projection for new trials, and the emergence of carboplatin. Sem Oncol ; 16 Suppl 6 — Begg AC. Cisplatin and radiation: interaction probabilities and therapeutic possibilities. Cisplatin potentiation of radiotherapy: long-term follow-up. Arch Otolaryngol ; — Cisplatin sensitization to radiotherapy in stage IV squamous cell carcinoma of the head and neck.

Arch Otolaryngol Head Neck Surg ; — Google Scholar. Simultaneous radiation therapy and cisplatin chemotherapy in advanced cancer of the head and neck. Am J Clin Oncol ; 10 — Preoperative simultaneously administered cisplatinum plus radiation therapy for advanced squamous cell carcinoma of the head and neck. Head Neck Surg ; 8 — Fountzilas G, et al. Radiation therapy and concurrent cisplatin administration in locally advanced head and neck cancer. Hellenic Co-operative Oncology Group study.

Acta Oncol ; 33 — Radiation and concurrent carboplatin administration in locally advanced head and neck cancer. A Hellenic Cooperative Oncology Group study. Tumori ; 81 — Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer.

N Engl J Med ; — Chemotherapy as a substitute for surgery in the treatment of advanced resectable head and neck cancer. A report from the Northern California Oncology Group. Cancer ; 60 — Pfister DG, et al. Larynx preservation with combined chemotherapy and radiation therapy in advanced resectable head and neck cancer. J Clin Oncol ; 9 — Nikolaou A, et al. Laryngeal preservation in cases of advanced laryngeal cancer treated with platinum based induction chemotherapy before local treatment.

J Laryngol Otol ; — American Joint Committee on Cancer. Manual for Staging on Cancer , 3 ed. Lippincott, Philadelphia. Agresti Alan, Categorical Data Analysis. Kaplan E, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assos ; 53 — Cox D. Regression models and life tables with discussion. J Royal Stat Soc B ; 34 — Moher D. JAMA ; — A randomised trial of neoadjuvant vs concomitant chemotherapy vs radiotherapy alone in the treatment of stage IV head and neck squamous cell carcinoma.

Eur Arch Otorhinolarygol ; — Taylor IV SG, et al. Randomized comparison of neoadjuvant cisplatin and fluorouracil infusion followed by radiation versus concomitant treatment in advanced head and neck cancer. J Clin Oncol ; 12 — Jeremic B, et al.

Radiation therapy alone or with concurrent low-dose daily either cisplatin or carboplatin in locally advanced unresectable squamous cell carcinoma of the head and neck: a prospective randomized trial. Radioth Oncol ; 43 — Wendt TG, et al. Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer: A randomized multicenter study.

J Clin Oncol ; 16 — Calais G, et al. Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst ; 91 — Adelstein DJ, et al. Mature results of a phase III randomized trial comparing concurrent chemoradiotherapy with radiation therapy alone in patients with stage III and IV squamous cell carcinoma of the head and neck. Cancer ; 88 — Fu KK, et al.

A radiation therapy oncology group RTOG phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation ot standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG Bachaud J-M, et al.

Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: Final report of a randomised trial. Brizel DM, et al. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer.

Hyperfractionated radiation therapy with or without concurrent low-dose daily cisplatin in locally advanced squamous cell carcinoma of the head and neck: A prospective randomised trial. J Clin Oncol ; 18 — Munro AJ. An overview of randomised controlled trials of adjuvant chemotherapy in head and neck cancer.

Br J Cancer ; 71 — El-Sayed S, Nelson N. Adjuvant and adjunctive chemotherapy in the management of squamous cell carcinoma of the head and neck region: A meta-analysis of prospective and randomised trial. J Clin Oncol ; 14 —

Completion of Radiotherapy for Local and Regional Head and Neck Cancer in Medicare

Treatment for patients with head and neck cancer requires a multidisciplinary approach. Radiotherapy is employed as a primary treatment or as an adjuvant to surgery. Each specific subsite dictates the appropriate radiotherapy techniques, fields, dose, and fractionation scheme. Quality of life is also an important issue in the management of head and neck cancer. The radiation-related complications have a tremendous impact on the quality of life. Modern radiotherapy techniques, such as intensity-modulated radiotherapy and image-guided radiotherapy, can offer precise radiation delivery and reduce the dose to the surrounding normal tissues without compromise of target coverage. In the future, efforts should be made in the exploration of novel strategies to improve treatment outcome in patients with head and neck cancer.

Radiotherapy for Head and Neck Cancer

Background : Locoregional recurrence is a predominant failure in locally advanced head and neck cancers despite of multimodality treatment including surgery and adjuvant chemoradiation. Analysis of locoregional failure pattern can contribute to improvement of future treatment. Objective : To evaluate pattern of failure in head and neck cancers treated with postoperative radiotherapy. Materials and Methods : Head and neck cancer patients who underwent postoperative radiotherapy in Thammasat hospital from October to January were retrospectively reviewed.

Frequency distribution of time elapsed from the diagnosis of head and neck cancer to the initiation of radiotherapy among patients with regional A and local B tumors. Frequency distribution of the number of radiotherapy treatments received by patients with regional A and local B tumors. Arch Otolaryngol Head Neck Surg. For each case, we calculated the timing and duration of radiotherapy using Medicare claims data.

Head and neck squamous cell carcinoma HNSCC accounts for more than , new cancer cases and over , deaths each year worldwide. After intrinsic tumour suppressor mechanisms fail, further tumour progression is the result of an inefficient elimination phase or equilibrium phase of the extrinsic tumour suppression by the immune system. Thus, they become invisible to immune cells by reducing the presentation of tumour antigens, decreasing their sensitivity to the cytotoxic effects of immune cells, and rendering their microenvironment immunosuppressive. Besides a well-known immunosuppressive effect of radiotherapy RT , it can also lead to positive alterations in innate and adaptive immunity. This combination was shown to cause similar toxicity compared to either RT or ICI alone across different cancer types.

Thank you for visiting nature. You are using a browser version with limited support for CSS.

GENERAL MANAGEMENT OF SPECIFIC CANCERS BY REGION

Наконец она остановилась, и дверь открылась. Покашливая, Сьюзан неуверенно шагнула в темный коридор с цементными стенами. Она оказалась в тоннеле, очень узком, с низким потолком. Перед ней, исчезая где-то в темноте, убегали вдаль две желтые линии. Подземная шоссейная дорога… Сьюзан медленно шла по этому туннелю, то и дело хватаясь за стены, чтобы сохранить равновесие.

 - Хейл вздохнул и повернулся к своему компьютеру. В этом вся ее сущность. Блестящий криптограф - и давнишнее разочарование Хейла. Он часто представлял, как занимается с ней сексом: прижимает ее к овальной поверхности ТРАНСТЕКСТА и берет прямо там, на теплом кафеле черного пола. Но Сьюзан не желала иметь с ним никакого дела.

The Slippery Role of Induction Chemotherapy in Head and Neck Cancer: Myth and Reality

Как правильно ответить.

2 Response
  1. Kiera K.

    This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK.

Leave a Reply