Reduced Expression Of Myc Increases Longevity And Enhances Healthspan Pdf

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A team of scientists based at Brown University has found that reducing expression of a fundamentally important gene called Myc significantly increased the healthy lifespan of laboratory mice, the first such finding regarding this gene in a mammalian species. Myc is found in the genomes of all animals, ranging from ancestral single-celled organisms to humans. It is a major topic of biomedical research and has been shown to be a central regulator of cell proliferation, growth, and death.

Reducing Myc gene increases lifespan of mice by 15% on average

So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone GH , IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 S6K1 knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin mTOR complex 1. The v-myc myelocytomatosis viral oncogene homolog MYC -deficient mice also exhibits a longevity phenotype. The gene expression profiles of these mice models have been measured to identify their longevity mechanisms. Here, we summarize our knowledge of long-lived mouse models related to growth and discuss phenotypic characteristics, including organ-specific gene expression patterns.

Reducing Myc gene increases lifespan of mice by 15% on average

The gene desert upstream of the MYC oncogene on chromosome 8q24 contains susceptibility loci for several major forms of human cancer. The region shows high conservation between human and mouse and contains multiple MYC enhancers that are activated in tumor cells. However, the role of this region in normal development has not been addressed. The mice are viable and show no overt phenotype. However, they are resistant to tumorigenesis, and most normal cells isolated from them grow slowly in culture.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Bats are the longest-lived mammals, given their body size.

Loss of gut integrity is linked to various human diseases including inflammatory bowel disease. However, the mechanisms that lead to loss of barrier function remain poorly understood. Using D. Reduction of dMyc in enterocytes induced cell death, which leads to increased gut permeability and reduced lifespan upon DR. Genetic mosaic and epistasis analyses suggest that cell competition, whereby neighboring cells eliminate unfit cells by apoptosis, mediates cell death in enterocytes with reduced levels of dMyc. We observed that enterocyte apoptosis was necessary for the increased gut permeability and shortened lifespan upon loss of dMyc. Furthermore, moderate activation of dMyc in the post-mitotic enteroblasts and enterocytes was sufficient to extend health-span on rich nutrient diets.


Reduced Expression of MYC Increases Longevity and Enhances Healthspan Myc+/− Mice Show Evidence of Improved Healthspan in Multiple Tissues Publisher's Disclaimer: This is a PDF file of an unedited manuscript.


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Address correspondence to Haim Y. E-mail: Haim. Cohen biu. The extension in human lifespan in the last century results in a significant increase in incidence of age related diseases.

MYC is a highly pleiotropic transcription factor whose deregulation promotes cancer. They show resistance to several age-associated pathologies, including osteoporosis, cardiac fibrosis and immunosenescence. They also appear to be more active, with a higher metabolic rate and healthier lipid metabolism.

Address correspondence to Haim Y. E-mail: Haim. Cohen biu. The extension in human lifespan in the last century results in a significant increase in incidence of age related diseases. It is therefore crucial to identify key factors that control elderly healthspan.

4 Response
  1. Dave R.

    Article. Reduced Expression of MYC Increases Longevity and Enhances Healthspan. Jeffrey W. Hofmann,1,7 Xiaoai Zhao,1,7 Marco De Cecco.

  2. Kassim W.

    Request PDF | Reduced Expression of MYC Increases Longevity and Enhances Healthspan | MYC is a highly pleiotropic transcription factor.

  3. Charlene L.

    Reduced Expression of MYC Increases Longevity and Enhances Healthspan (katcompany.org). Myc+/– Mice Show Evidence of Improved Healthspan in Multiple Tissues.

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